ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v13i6.1677ppharm-1488Research ArticleВ ПРАКТИКУ ПЕДИАТРАFor Pediatricians' PracticeВОЗМОЖНОСТИ ПРИМЕНЕНИЯ ЛАКТОФЕРРИНА У ДЕТЕЙ ПЕРВОГО ГОДА ЖИЗНИLACTOFERIN IN THE PROBLEM OF ANTI-INFECTIOUS PROTECTION OF BABIES IN THEIR FIRST YEAR OF LIVINGСадчиковП. Е.SadchikovP. E.

Садчиков Павел Евгеньевич - аспирант отделения для недоношенных детей НЦЗД.

119991, Москва, Ломоносовский пр-т, д. 2 стр. 1, тел.: +7 (968) 708-01-40, e-mail: borovik@nczd.ru

Moscow

borovik@nczd.ruГольдманИ. Л.GoldmanI. G.

Москва

Moscow

https://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaL. S.ЯцыкГ. В.YatsikG. V.

Москва

Moscow

https://orcid.org/0000-0002-0603-3394БоровикТ. Э.BorovikT. E.

Moscow

ЧерноусовА. Д.ChernousovA. D.

Москва

Moscow

РоманченкоА. И.RomanchenkoА. I.

Москва

Moscow

СадчиковаЕ. Р.SadchikovaE. R.

Москва

Moscow

https://orcid.org/0000-0002-5876-691XЛукояноваО. Л.LukoyanovaO. L.

Москва

Moscow

https://orcid.org/0000-0002-0709-1115ЗвонковаН. Г.ZvonkovaN. G.

Moscow

БеляеваИ. А.BelyaevaI. A.

Москва

Moscow

Научный центр здоровья детейРоссияScientific Center of Children’s HealthRussian FederationИнститут биологии генаРоссияInstitute of Gene BiologyRussian FederationНаучный центр здоровья детей; Первый Московский государственный медицинский университет имени И.М. Сеченова; Российский национальный исследовательский медицинский университет имени Н.И. ПироговаРоссияScientific Center of Children’s Health; Sechenov First Moscow State Medical University; N.I. Pirogov Russian National Research Medical UniversityRussian FederationНаучный центр здоровья детей; Первый Московский медицинский государственный университет имени И.М. СеченоваРоссияScientific Center of Children’s Health; Sechenov First Moscow State Medical UniversityRussian FederationИнститут биологии гена; Институт иммунологии, Государственный научный центрРоссияInstitute of Gene Biology; Institute of Immunology, State Science CenterRussian Federation201616022017136607613Copyright © Садчиков П.Е., Гольдман И.Л., Намазова-Баранова Л.С., Яцык Г.В., Боровик Т.Э., Черноусов А.Д., Романченко А.И., Садчикова Е.Р., Лукоянова О.Л., Звонкова Н.Г., Беляева И.А., 20172017Садчиков П.Е., Гольдман И.Л., Намазова-Баранова Л.С., Яцык Г.В., Боровик Т.Э., Черноусов А.Д., Романченко А.И., Садчикова Е.Р., Лукоянова О.Л., Звонкова Н.Г., Беляева И.А.Sadchikov P.E., Goldman I.G., Namazova-Baranova L.S., Yatsik G.V., Borovik T.E., Chernousov A.D., Romanchenko А.I., Sadchikova E.R., Lukoyanova O.L., Zvonkova N.G., Belyaeva I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/1488

В статье обобщены результаты исследований, посвященных изучению антибактериальных, противовирусных и противогрибковых свойств многофункционального белка человека — лактоферрина, для определения перспектив его применения с целью профилактики и лечения инфекционной патологии у детей первого года жизни. Описаны механизмы противоинфекционного действия этого белка у детей, находящихся на грудном вскармливании. Показаны основные различия между лактоферрином человека и лактоферрином крупного рогатого скота. Описана биотехнология получения рекомбинантного лактоферрина человека из молока генно-инженерных молочных животных (коз-продуцентов). Согласно проведенным исследованиям, как по физико-химическим параметрам, так и по биологической активности лактоферрин  человека, выделенный из молока коз-продуцентов, соответствует его природному аналогу.

The author  summarizes  the  results  of research  of the  antibacterial,  antiviral  and  antifungal  properties  of multifunctional  human protein  — lactoferrin,  in order  to determine  the prospects  for its use in the prevention  and  treatment  of infectious  diseases  of children in their first year of life. The mechanisms of anti-infectious effect of this protein with breastfed children have been described. Basic differences between human lactoferrin and cattle lactoferrin have been shown. Biotechnology of obtaining recombinant human lactoferrin from the milk of genetically engineered dairy animals (goat-producers) has been described. According to the studies, both by physical and chemical parameters and biological activity, human lactoferrin, obtained from milk-producing  goats, corresponds to its natural counterpart.

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The authors declare that there are no conflicts of interest present.