ppharmПедиатрическая фармакологияPediatric pharmacology1727-57762500-3089Издательство «ПедиатрЪ»10.15690/pf.v13i1.1517ppharm-1385Research ArticleВ ПРАКТИКУ ПЕДИАТРАFor Pediatricians' PracticeЗУДЯЩИЕ ДЕРМАТОЗЫ С ХРОНИЧЕСКИМ ТЕЧЕНИЕМ В ДЕТСКОМ ВОЗРАСТЕ: СОВРЕМЕННЫЕ МЕТОДЫ ЛЕЧЕНИЯ И ЭФФЕКТИВНОГО КУПИРОВАНИЯ СУБЪЕКТИВНЫХ ЖАЛОБCHRONIC ITCHING DERMATOSIS IN CHILDREN: MODERN METHODS OF TREATMENT AND EFFICIENT TERMINATION OF SUBJECTIVE COMPLAINTSМурашкинН. Н.MurashkinN. N.

Москва

Moscow

АмбарчянЭ. Т.AmbarchyanE. T.

Москва

Moscow

МатерикинА. И.MaterikinA. I.

Москва

Moscow

ЕпишевР. В.EpishevR. V.

Москва

Moscow

Научный центр здоровья детейРоссияScientific Center of Children’s HealthRussian Federation2016130220161315962Copyright © Мурашкин Н.Н., Амбарчян Э.Т., Материкин А.И., Епишев Р.В., 20162016Мурашкин Н.Н., Амбарчян Э.Т., Материкин А.И., Епишев Р.В.Murashkin N.N., Ambarchyan E.T., Materikin A.I., Epishev R.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.pedpharma.ru/jour/article/view/1385

В статье представлены современные данные об особенностях этиологии и патогенеза зудящих дерматозов с хроническим течением у детей. Приведена классификация различных форм зуда и патофизиологический механизм его развития, лежащего в основе хронических заболеваний кожи. Освещены результаты клинических исследований эффективности и безопасности метилпреднизолона ацепоната в лечении зудящих дерматозов в детском возрасте.

The article presents contemporary data on the peculiarities of etiology and pathogenesis of chronic itching dermatosis in children. We provide classification of various itching forms and pathophysiological mechanism of the development thereof underlying chronic skin disorders. We describe results of clinical studies of effectiveness and safety of methylprednisolone aceponate for treating itching dermatosis in children.

детизудметилпреднизолона ацепонатchildrenitchingmethylprednisolone aceponateкомпании Jansen, Eli LillyReferencesWeisshaar E, Szepietowski JC, Darsow U, Misery L, Wallengren J, Mettang T, Gieler U, Lotti T, Lambert J, Maisel P, Streit M, Greaves MW, Carmichael AJ, Tschachler E, Ring J, Stander S. European guideline on chronic pruritus. Acta Derm Venereol. 2012;92:563–568.Weisshaar E, Szepietowski JC, Darsow U, Misery L, Wallengren J, Mettang T, Gieler U, Lotti T, Lambert J, Maisel P, Streit M, Greaves MW, Carmichael AJ, Tschachler E, Ring J, Stander S. European guideline on chronic pruritus. Acta Derm Venereol. 2012;92:563–568.Metz M, Stander S. Сhronic pruritus — pathogenesis, clinical aspects and treatment. J Eur Acad Dermatol Venereol. 2010;24:1249–1260.Metz M, Stander S. Сhronic pruritus — pathogenesis, clinical aspects and treatment. J Eur Acad Dermatol Venereol. 2010;24:1249–1260.Metz M, Wahn U, Gieler U, Stock P, Schmitt J, Blume-Peytavi U. Chronic pruritus associated with dermatologic disease in infancy and childhood: update from an interdisciplinary group of dermatologists and pediatricians. Pediatr Allergy Immunol. 2013;24(6):527–539.Metz M, Wahn U, Gieler U, Stock P, Schmitt J, Blume-Peytavi U. Chronic pruritus associated with dermatologic disease in infancy and childhood: update from an interdisciplinary group of dermatologists and pediatricians. Pediatr Allergy Immunol. 2013;24(6):527–539.Адаскевич ВП. Кожный зуд. Дерматологический и междисциплинарный феномен. М.: Изд-во Панфилова. 2014. С. 27–97.Адаскевич ВП. Кожный зуд. Дерматологический и междисциплинарный феномен. М.: Изд-во Панфилова. 2014. С. 27–97.Weisshaar E, Dalgard F. Epidemiology of itch: adding to the burden of skin morbidity. Acta Derm Venereol. 2009;89:339–350.Weisshaar E, Dalgard F. Epidemiology of itch: adding to the burden of skin morbidity. Acta Derm Venereol. 2009;89:339–350.Kay J, Gawkrodger DJ, Mortimer MJ, Jaron AG. The prevalence of childhood atopic eczema in a general population. J Am Acad Dermatol. 1994;30:35–39.Kay J, Gawkrodger DJ, Mortimer MJ, Jaron AG. The prevalence of childhood atopic eczema in a general population. J Am Acad Dermatol. 1994;30:35–39.Weisshaar E, Diepgen TL, Luger TA, Seeliger S, Witteler R, Stander S. Pruritus in pregnancy and childhood do we really consider all relevant differential diagnoses? Eur J Dermatol. 2005;15:320–331.Weisshaar E, Diepgen TL, Luger TA, Seeliger S, Witteler R, Stander S. Pruritus in pregnancy and childhood do we really consider all relevant differential diagnoses? Eur J Dermatol. 2005;15:320–331.Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M, Eigenmann P, Hamid Q, Kapp A, Leung DY, Lipozencic J, Luger TA, Muraro A, Novak N, Platts-Mills TA, Rosenwasser L, Scheynius A, Simons FE, Spergel J, Turjanmaa K, Wahn U, Weidinger S, Werfel T, Zuberbier T. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology. American Academy of Allergy, Asthma and Immunology. PRACTALL Consensus Report. J Allergy Clin Immunol. 2006;118:152–169.Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M, Eigenmann P, Hamid Q, Kapp A, Leung DY, Lipozencic J, Luger TA, Muraro A, Novak N, Platts-Mills TA, Rosenwasser L, Scheynius A, Simons FE, Spergel J, Turjanmaa K, Wahn U, Weidinger S, Werfel T, Zuberbier T. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology. American Academy of Allergy, Asthma and Immunology. PRACTALL Consensus Report. J Allergy Clin Immunol. 2006;118:152–169.Gupta D. Atopic Dermatitis A Common Pediatric Condition and Its Evolution in Adulthood. Med Clin North Am. 2015;99(6):1269–1285.Gupta D. Atopic Dermatitis A Common Pediatric Condition and Its Evolution in Adulthood. Med Clin North Am. 2015;99(6):1269–1285.Su JC, Kemp AS, Varigos GA, Nolan TM. Atopic eczema: its impact on the family and financial cost. Arch Dis Child. 1997;76:159–162.Su JC, Kemp AS, Varigos GA, Nolan TM. Atopic eczema: its impact on the family and financial cost. Arch Dis Child. 1997;76:159–162.Lawson V, Lewis-Jones MS, Finlay AY, Reid P, Owens RG. The family impact of childhood atopic dermatitis: the Dermatitis Family Impact Questionnaire. Br J Dermatol. 1998;138:107–113.Lawson V, Lewis-Jones MS, Finlay AY, Reid P, Owens RG. The family impact of childhood atopic dermatitis: the Dermatitis Family Impact Questionnaire. Br J Dermatol. 1998;138:107–113.Warschburger P, Buchholz HT, Petermann F. Psychological adjustment in parents of young children with atopic dermatitis: which factors predict parental quality of life? Br J Dermatol. 2004;150:304–311.Warschburger P, Buchholz HT, Petermann F. Psychological adjustment in parents of young children with atopic dermatitis: which factors predict parental quality of life? Br J Dermatol. 2004;150:304–311.Al Shobaili HA. The impact of childhood atopic dermatitis on the patients’ family. Pediatr Dermatol. 2010;27:618–623.Al Shobaili HA. The impact of childhood atopic dermatitis on the patients’ family. Pediatr Dermatol. 2010;27:618–623.Eichenfield LF, Tom WL, Berger TG, Krol A, Paller AS, Schwarzenberger K, Bergman JN, Chamlin SL, Cohen DE, Cooper KD, Cordoro KM, Davis DM, Feldman SR, Hanifin JM, Margolis DJ, Silverman RA, Simpson EL, Williams HC, Elmets CA, Block J, Harrod CG, Smith Begolka W, Sidbury R. Guidelines of care for the management of atopic dermatitis: Section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71(1):116–132.Eichenfield LF, Tom WL, Berger TG, Krol A, Paller AS, Schwarzenberger K, Bergman JN, Chamlin SL, Cohen DE, Cooper KD, Cordoro KM, Davis DM, Feldman SR, Hanifin JM, Margolis DJ, Silverman RA, Simpson EL, Williams HC, Elmets CA, Block J, Harrod CG, Smith Begolka W, Sidbury R. Guidelines of care for the management of atopic dermatitis: Section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71(1):116–132.Carbone A, Siu A, Patel R. Pediatric atopic dermatitis: a review of the medical management. Ann Pharmacother. 2010;44(9): 1448–1458.Carbone A, Siu A, Patel R. Pediatric atopic dermatitis: a review of the medical management. Ann Pharmacother. 2010;44(9): 1448–1458.Herguner S, Kilic G, Karakoc S, Tamay Z, Tuzun U, Guler N. Levels of depression, anxiety and behavioural problems and frequency of psychiatric disorders in children with chronic idiopathic urticaria. Br J Dermatol. 2011;164:1342–1347.Herguner S, Kilic G, Karakoc S, Tamay Z, Tuzun U, Guler N. Levels of depression, anxiety and behavioural problems and frequency of psychiatric disorders in children with chronic idiopathic urticaria. Br J Dermatol. 2011;164:1342–1347.O’Donnell BF, Lawlor F, Simpson J, Morgan M, Greaves MW. The impact of chronic urticaria on the quality of life. Br J Dermatol. 1997;136:197–201.O’Donnell BF, Lawlor F, Simpson J, Morgan M, Greaves MW. The impact of chronic urticaria on the quality of life. Br J Dermatol. 1997;136:197–201.Greaves MW. Chronic urticaria in childhood. Allergy. 2000; 55:309–320.Greaves MW. Chronic urticaria in childhood. Allergy. 2000; 55:309–320.Yosipovicg G, Goon A, Wee J, Chan YH, Goh GL. The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis. Br J Dermatol. 2000;143:969–973.Yosipovicg G, Goon A, Wee J, Chan YH, Goh GL. The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis. Br J Dermatol. 2000;143:969–973.Yosipovicg G, Greaves MW, Schmelz M. Itch. Lancet. 2003; 351:690–694.Yosipovicg G, Greaves MW, Schmelz M. Itch. Lancet. 2003; 351:690–694.Turpeinen M. Influence of age and severity of dermatitis on the percutaneous absorption of hydrocortisone in children. Br J Dermatol. 1988;118:517–522.Turpeinen M. Influence of age and severity of dermatitis on the percutaneous absorption of hydrocortisone in children. Br J Dermatol. 1988;118:517–522.Ruzicka T. Methylprednisolone aceponate in eczema and other inflammatory skin disorders — a clinical update. Int J Clin Pract. 2006;60(1):85–92.Ruzicka T. Methylprednisolone aceponate in eczema and other inflammatory skin disorders — a clinical update. Int J Clin Pract. 2006;60(1):85–92.Garcia Ponte L, Ebert U. Frontiers of rapid itch relief: a review of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2012;26(Suppl.6):9–13.Garcia Ponte L, Ebert U. Frontiers of rapid itch relief: a review of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2012;26(Suppl.6):9–13.Blume-Peytavi U, Wahn U. Optimizing the treatment of atopic dermatitis in children: a review of the benefit/risk ratio of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2011; 25(5):508–515.Blume-Peytavi U, Wahn U. Optimizing the treatment of atopic dermatitis in children: a review of the benefit/risk ratio of methylprednisolone aceponate. J Eur Acad Dermatol Venereol. 2011; 25(5):508–515.

The authors declare that there are no conflicts of interest present.