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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ppharm-1152</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПРАКТИКУ ПЕДИАТРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>For Pediatricians' Practice</subject></subj-group></article-categories><title-group><article-title>КЛИНИЧЕСКИ ИЗОЛИРОВАННЫЙ СИНДРОМ У ДЕТЕЙ И ПОДРОСТКОВ — ФАКТОРЫ РИСКА РАССЕЯННОГО СКЛЕРОЗА И ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ ВНУТРИМЫШЕЧНОГО ИНТЕРФЕРОНА БЕТА-1А</article-title><trans-title-group xml:lang="en"><trans-title>CLINICALLY ISOLATED SYNDROME IN CHILDREN AND ADOLESCENTS — RISK FACTORS FOR MULTIPLE SCLEROSIS AND PROSPECTS OF USING INTRAMUSCULAR INTERFERON β-1A</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Быкова</surname><given-names>О.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bykova</surname><given-names>O.V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Платонова</surname><given-names>А.Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Platonova</surname><given-names>A.N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шатилова</surname><given-names>Н.Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shatilova</surname><given-names>N.N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аникин</surname><given-names>А.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Anikin</surname><given-names>A.V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузенкова</surname><given-names>Л.М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzenkova</surname><given-names>L.M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>07</day><month>12</month><year>2015</year></pub-date><volume>7</volume><issue>3</issue><issue-title>Педиатрическая фармакология</issue-title><fpage>91</fpage><lpage>94</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Быкова О., Платонова А., Шатилова Н., Аникин А., Кузенкова Л., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Быкова О., Платонова А., Шатилова Н., Аникин А., Кузенкова Л.</copyright-holder><copyright-holder xml:lang="en">Bykova O., Platonova A., Shatilova N., Anikin A., Kuzenkova L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/1152">https://www.pedpharma.ru/jour/article/view/1152</self-uri><abstract><p>Клинически изолированным синдромом называют первый демиелинизирующий эпизод в структуре рассеянного склероза, то есть клинический дебют заболевания, требующий обширного дифференциально-диагностического поиска и определения долгосрочной терапевтической тактики. Известно, что опыт назначения взрослым больным интерферонов бета именно на этом, максимально раннем этапе заболевания, приводит к значительному улучшению отдаленного прогноза инвалидизации. В то же время, перспективные методики раннего начала иммуномодулирующей терапии пока не нашли достаточного распространения у детей и подростков с рассеянным склерозом. Ключевые слова: рассеянный склероз, клинически изолированный синдром, дети, подростки, интерферон бета.</p><p>(Педиатрическая фармакология. – 2010; 7(3):91-94)</p></abstract><trans-abstract xml:lang="en"><p>The first demyelinating episode in the structure of multiple sclerosis is called clinically isolated syndrome, that is the clinical debut of the disease requiring an extensive differential diagnostic search and identification of long-term therapeutic tactics. It is well-known that experience of prescribing interferon β to adult patients at this earliest stage in the disease results in a substantially improved long-term disability prognosis. At the same time, promising techniques for an early launch of the biologic response modifier therapy have not yet found sufficient application in children and adolescents with multiple sclerosis.Key words: multiple sclerosis, clinically isolated syndrome, children, adolescents, interferon β. </p><p> (Pediatric Pharmacology. – 2010; 7(3):91-94)</p></trans-abstract></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
