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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ppharm-1080</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПРАКТИКУ ПЕДИАТРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>For Pediatricians' Practice</subject></subj-group></article-categories><title-group><article-title>МИКРОЭКОЛОГИЧЕСКИЕ И ФУНКЦИОНАЛЬНЫЕ НАРУШЕНИЯ КИШЕЧНИКА ПРИ ХРОНИЧЕСКОМ ЗАПОРЕ У ДЕТЕЙ. МЕТОДЫ КОРРЕКЦИИ</article-title><trans-title-group xml:lang="en"><trans-title>MICROECOLOGICAL AND FUNCTIONAL ABNORMALITIES OF INTESTINES IN CHILDREN WITH CHRONIC CONSTIPATION. METHODS OF CORRECTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комарова</surname><given-names>Е.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Komarova</surname><given-names>E.V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>04</day><month>12</month><year>2015</year></pub-date><volume>7</volume><issue>6</issue><issue-title>Педиатрическая фармакология</issue-title><fpage>74</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Комарова Е., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Комарова Е.</copyright-holder><copyright-holder xml:lang="en">Komarova E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/1080">https://www.pedpharma.ru/jour/article/view/1080</self-uri><abstract><p>Работа посвящена вопросам микроэкологии желудочно-кишечного тракта у детей с хроническим запором. Приведены результаты собственных наблюдений. Обследован 51 ребенок с хроническим запором. Комплексная оценка микро-экологических и функциональных нарушений кишечника при данной патологии выявила сниженный уровень коротко-цепочечных жирных кислот и анаэробного индекса, дисбактериоз 1 и 2 степеней, нарушение пищеварения в тонком кишечнике. Изменения метаболической активности микрофлоры кишечника соответствовали функциональному состоянию ЖКТ. Один из методов терапии хронического запора — восстановление нормальной микрофлоры толстой кишки. При воздействии на патогенную микрофлору необходимо использование сорбентов. Ключевые слова: хронический запор, лечение, энтеросорбенты, диоктаэдрический смектит, дети. </p><p>(Педиатрическая фармакология. – 2010; 7(6):74-76)</p></abstract><trans-abstract xml:lang="en"><p>The work contains the follow-up results obtained by the author himself. 51 children with chronic constipation were studied. A complex assessment of microecological and functional abnormalities of intestines in this pathology revealed a reduced level of short-chain fatty acids and anaerobic index, degree I and II dysbiosis, digestion disorder in small intestines. Changes in metabolic activity of intestinal microflora were in line with the functional state of GIT. One of therapy methods for chronic constipation is restoration of normal microflora of large intestines. Absorbents need to be used to influence the pathogenic microflora. Kew words: chronic constipation, treatment, enterosorbents, dioctahedral smectite, children. </p><p>(Pediatric Pharmacology. – 2010; 7(6):74-76)</p></trans-abstract></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
