<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ppharm</journal-id><journal-title-group><journal-title xml:lang="ru">Педиатрическая фармакология</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric pharmacology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-5776</issn><issn pub-type="epub">2500-3089</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/pf.v11i3.1015</article-id><article-id custom-type="elpub" pub-id-type="custom">ppharm-104</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПРАКТИКУ ПЕДИАТРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>For Pediatricians' Practice</subject></subj-group></article-categories><title-group><article-title>ЛЕЧЕНИЕ АФТОЗНОГО СТОМАТИТА У ПОДРОСТКОВ</article-title><trans-title-group xml:lang="en"><trans-title>TREATMENT OF APHTHOUS STOMATITIS IN ADOLESCENTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлова</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlova</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка второго курса стоматологического факультета Первого МГМУ им. И.М. Сеченова</p></bio><bio xml:lang="en"><p>sophomore at the faculty of dentistry of the First Moscow State Medical University</p></bio><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зорина</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zorina</surname><given-names>O. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрухина</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrukhina</surname><given-names>N. B.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская Федерация</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University, Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>03</day><month>06</month><year>2014</year></pub-date><volume>11</volume><issue>3</issue><issue-title>Педиатрическая фармакология</issue-title><fpage>85</fpage><lpage>88</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Козлова Л.М., Зорина О.А., Петрухина Н.Б., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Козлова Л.М., Зорина О.А., Петрухина Н.Б.</copyright-holder><copyright-holder xml:lang="en">Kozlova L.M., Zorina O.A., Petrukhina N.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.pedpharma.ru/jour/article/view/104">https://www.pedpharma.ru/jour/article/view/104</self-uri><abstract/><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance: therapeutic tactics at infectious inflammatory conditions of oral and pharyngeal mucosae includes prescription of the drugs featuring antimicrobial, anti-inflammatory and analgesic action. A combination of tyrothricin (antibacterial agent), benzocaine (topical anesthetic agent) and benzalkonium chloride (antiseptic) has been in use in clinical practice for years. The study was aimed at comparing the clinical efficacy of the drug based on the listed active substances and other stomatological agents in adolescents with aphthous stomatitis. Results: comparable efficacy of the drugs under study has been observed. No side effects have been observed within the period of the drug’s use. A possibility to use one drug for treatment facilitates oral care and improves compliance of patients.</p></sec><sec><title> </title><p> </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>афтозный стоматит</kwd><kwd>лечение</kwd><kwd>тиротрицин</kwd><kwd>комбинированные препараты</kwd><kwd>эффективность</kwd><kwd>безопасность</kwd><kwd>подростки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>aphthous stomatitis</kwd><kwd>treatment</kwd><kwd>tyrothricin</kwd><kwd>combined drugs</kwd><kwd>efficacy</kwd><kwd>safety</kwd><kwd>adolescents</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимова И. В., Недосеко В. Б., Ломиашвили Л. M. Заболевания слизистой оболочки рта и губ (клиника, диагностика). СПб.: ООО «МЕДИ-издательство». 2005. 92 с.</mixed-citation><mixed-citation xml:lang="en">Anisimova I. V., Nedoseko V. B., Lomiashvili L. M. Zabolevaniya slizistoi obolochki rta i gub (klinika, diagnostika) [Diseases of Mucosae of the Mouth and Lips (Clinical Pattern, Diagnosis)]. St. Petersburg, OOO «MEDI-izdatel'stvo», 2005. 92 p.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Барер Г. М., Ионов В. А. Состояние микробиоценоза слизистой оболочки полости рта при хроническом рецидивирующем афтозном стоматите. Cathedra. 2008; 6 (4): 24–27.</mixed-citation><mixed-citation xml:lang="en">Barer G.M., Ionov V. A. Cathedra = Cathedra. 2008; 6 (4): 24–27.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Данилевский Н. Ф., Леонтьев В. К., Несин А. Ф. и др. Заболевания слизистой оболочки полости рта. М.: ОАО «Стоматология». 2001. 271 с.</mixed-citation><mixed-citation xml:lang="en">Danilevskii N.F., Leont'ev V.K., Nesin A.F. et al. Zabolevaniya slizistoi obolochki polosti rta [Diseases of Oral Mucosa]. Moscow, OAO «Stomatologiya». 2001, 271 p.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Рабинович И. М., Банченко Г. В. Рецидивирующий афтозный стоматит. Клиника, диагностика и лечение. Клиническая стоматология. 1998; 3: 26–28.</mixed-citation><mixed-citation xml:lang="en">Rabinovich I.M., Banchenko G.V. Klinicheskaya stomatologiya = Clinical stomatology. 1998; 3: 26–28.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Дроботько Л. H., Страхова С. Ю. Хронический рецидивирующий афтозный стоматит Электронный ресурс. Режим доступа: http://www.rmj.ru/articles4376.htm</mixed-citation><mixed-citation xml:lang="en">Drobot'ko L. H., Strakhova S. Yu. Khronicheskii retsidiviruyushchii aftoznyi stomatit [Chronic recurrent aphthous stomatitis]. Available at: http://www.rmj.ru/articles4376.htm</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Страхова С. Ю. Новые лекарственные препараты в комплексном лечении острого герпетического стоматита у детей. Автореф. дис. … канд. мед. наук. М., 2000. 24 с.</mixed-citation><mixed-citation xml:lang="en">Strakhova S. Yu. Novye lekarstvennye preparaty v kompleksnom lechenii ostrogo gerpeticheskogo stomatita u detei. Avtoref. dis. … kand. med. nauk [New Drugs for Complex Treatment of Acute Herpetic Stomatitis in Children. Author’s abstract]. Moscow, 2000. 24 p.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rees T. D., Binnie W. H. Reccurent aphthous stomatitis. Dermatol Clin. 1996; 14: 243–256.</mixed-citation><mixed-citation xml:lang="en">Rees T. D., Binnie W. H. Reccurent aphthous stomatitis. Dermatol. Clin. 1996; 14: 243–256.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Егоров Н. С. Основы учения об антибиотиках. М.: Высшая школа. 1989. 456 с.</mixed-citation><mixed-citation xml:lang="en">Egorov N. S. Osnovy ucheniya ob antibiotikakh [Antibiotics: Basic Principles]. Moscow, Vysshaya shkola, 1989. 456 p.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ланчини Д., Паренти Ф. Антибиотики. М.: Мир. 1985. 460 с.</mixed-citation><mixed-citation xml:lang="en">Lancini D., Parenti F. Antibiotiki [Antibiotics]. Moscow, Mir, 1985. 460 p.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Dinnendahl V., Fricke U. Benzocain. In: Dinnendahl V., Fricke U., editors. Arzneistoffprofile (ASP). Frankfurt-Main: Govi-Verlag GmbH. 1982.</mixed-citation><mixed-citation xml:lang="en">Dinnendahl V., Fricke U. Benzocain. In: Dinnendahl V., Fricke U., editors. Arzneistoffprofile (ASP). Frankfurt-Main, Govi-Verlag GmbH, 1982.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Adriani J., Taylor M. K. Benzocaine`s Properties and Uses as a Topical Anesthetic. Anesthesiology. 1990; XVII (1): 27–33.</mixed-citation><mixed-citation xml:lang="en">Adriani J., Taylor M. K. Benzocaine`s Properties and Uses as a Topical Anesthetic. Anesthesiology. 1990; XVII (1): 27–33.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Woo S. B., Sonis S. T. Recurrent aphthous ulcers: A review if diagnosis and treatment. JADA. 1996; 127: 1202–1213.</mixed-citation><mixed-citation xml:lang="en">Woo S. B., Sonis S. T. Recurrent aphthous ulcers: A review if diagnosis and treatment. JADA. 1996; 127: 1202–1213.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
